Sandia National Laboratories
Brian M. Adams
Biography and CV
Contact Information


I am an applied mathematician working in the Optimization and Uncertainty Estimation department in the Computation, Computers, Information and Mathematics center. My academic background is in mathematical biology, but my research interests in computational mathematics are more broad, with strong ties to applications.

Research Interests

  • Inverse problems and sensitivity analysis with engineering and biological models using simulated and/or experimental data. Model calibration and extrapolation under uncertainty.
  • Algorithms combining optimization and uncertainty quantification. Non-intrusive methods for efficient uncertainty quantification.
  • Modeling and control theory, especially with biological applications, including population dynamics, in-host infection dynamics and optimal treatment interruption strategies.
  • Scientific computation, including simulation of models, optimization, and parallel computing.
  • Close collaboration with mathematicians, statisticians, engineers, and other disciplinary scientists to model systems and analyze data.

Current Projects

  • Dakota is a freely available software framework for large-scale engineering optimization and uncertainty analysis. I lead Dakota product development.

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Brian M. Adams
Principal Member of Technical Staff
(505) 284-8845